IgG4-Related Systemic Disease Can Be Easily Mistaken as a Uroepithelial Tumor
نویسندگان
چکیده
Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic syndrome characterized by elevated serum IgG4 concentrations and tumefaction or tissue infiltration by IgG4-positive plasma cells. We experienced a case of IgG4-RD involving multiple organs in a 64-year-old female who was referred for a suspected uroepithelial tumor. A mass biopsy confirmed dense lymphoplasmacytic infiltration with an increased number of IgG4-positive plasma cells. We discuss this case and review the literature to bring IgG4-RD to the attention to clinicians because it responds dramatically well to steroid therapy and should be kept in mind as a differential diagnosis to avoid unnecessary surgery.
منابع مشابه
ویژگی ها IgG4 و بیماری های مرتبط با IgG4
Abstract Background: In the serum of healthy people, IgG4 has lowest concentration among the different sub-classes of IgG. Elevation of serum IgG4 in response to chronic antigenic stimulation and inflammation has been reported. Inflammation, histopathologic lesions and systemic organ involvement have been reported in the IgG4-related disease (IgG4-RD). In this article we review IgG4 unique f...
متن کاملHypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease.
Immunoglobulin (Ig) G4-related systemic disease is a recently characterized entity. The best-known manifestation is pancreatitis. Other systemic involvements are also described. Three cases of this disease with hypophyseal involvement have been reported in the literature, all diagnosed clinically. We herein present the first case of IgG4-related hypophysitis diagnosed histopathologically. The p...
متن کاملIgG4-related Kidney Disease Mimicking Malignant Ureter Tumor
Immunoglobulin G4-related disease is a recently recognized systemic disease that can affect any organ or tissue in the body, including the kidneys. IgG4-related kidney disease (IgG4-RKD) is an important part of immunoglobulin G4-related disease. The most common renal manifestation of IgG4-RKD is tubulointerstitial nephritis and glomerular lesions. There, however, is few case of IgG4-RKD mimicki...
متن کاملAutoimmune Pancreatitis: A Case of Atypical Radiographic Findings
Autoimmune pancreatitis (AIP) is a rare pancreatic disorder that can present as a manifestation of a broader systemic inflammatory disease known as immunoglobulin G4-related systemic disease (IGG4-RSD). AIP is divided into two subtypes based on clinical, radiological, and histological findings. The disease can be mistaken for pancreatic cancer because of overlapping clinical and radiological fi...
متن کاملDermatological aspects of immunoglobulin G4 (IgG4)-related disease.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease characterized by lymphoplasmacytic inflammation, fibrosis, and elevated levels of IgG4 in tissues and eventually in the blood. IgG4-RD is a recently described disease and encompasses classic entities such as Riedel’s thyroiditis, Mikulicz syndrome, and Küttner’s tumor. It is a rare disease that affects middle-aged men, especially...
متن کامل